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Biophysical studies in individual living cells enable a quantitative understanding of the structures and dynamics of macromolecules and cellular processes in their own physiological context. This is a...
Basic biological needs, such as food, sleep or sex, modulate many physiological processes and drive the evolution of highly specialized and complex behaviors. The intensity and complexity of such biol...
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
Biophysical studies in individual living cells enable a quantitative understanding of the structures and dynamics of macromolecules and cellular processes in their own physiological context. This is a...
The fluorescence intensity from randomly oriented Rhodobacter ( Rb.) sphaeroides photosynthetic reaction centers at 77 K increases in an applied electric field. This is ascribed to a net reduction in ...
In this paper we show that nuclear spin networks in neural membranes are modulated by action potentials through J-coupling, dipolar coupling and chemical shielding tensors and perturbed by microscopic...
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Motoneurons of the spinal nucleus of the bulbocavernosus (SNB) reside in the lower lumbar spinal cord and innervate the bulbocavernosus (BC) and levator ani (LA) muscles. Adult males have larger BC an...
Many plant RNA viruses provide replication and encapsidation functions for one or more subviral RNAs that can modulate the symptoms of the associated helper virus. In this dissertation, I report my st...
Mice with a deletion of the hypothalamic basic helix-loop-helix transcription factor Nhlh2 (N2KO) display adult onset obesity, implicating Nhlh2 in the neuronal circuits regulating energy availability...
Liu CY, Mueller MH, Grundy D, Kreis ME. Vagal modulation of intestinal afferent sensitivity to systemic LPS in the rat. Am J Physiol Gastrointest Liver Physiol 292: G1213–G1220, 2007. First published ...

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