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Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate（EDS）can take place in the absence of LH
proliferation differentiation Leydig cell precursors
2009/2/23
In hypophysectomized rats, 2 days after the administration of the cytotoxic drug ethane dimethyl sulphonate (EDS), the proliferative activity of Leydig cell precursors increased six-fold. Thus, fact...
The regulation of the proliferation and differentiation of rat Leydig cell precursor cells after EDS administration or daily HCG treatment
Leydig cell Leydig cell precursor LH hCG EDS proliferation
2009/2/23
The proliferation and differentiation of possible Leydig cell precursors in adult rats were studied after destruction of the existing Leydig cells with EDS or after daily treatment with hCG. After 2...
Differential effects of（+）and（-）gossypol enantiomers on mitochondrial function and proliferation of cultured TM4 cells
Gossypol isomer TM4 cells mitochondria
2009/2/23
The in vitro effects of (+) and (-)gossypol enantiomers on the mitochondrial functions of mouse transformed Sertoli, TM4 cells were investigated by monitoring mitochondrial rhodamine 123 accumulat...
Suppression of the proliferative response of the seminal vesicles to testosterone by inhibitors of prostaglandin synthesis. Testosterone, indomethacin, and proliferation in seminal vesicles
seminal vesicles testosterone prostaglandin synthesis
2009/2/19
Effects of indomethacin (1.25 mg/kg) and aspirin (20 mg/kg) on testosterone-induced (0.25 mg/rat), and of indomethacin on dihydrotestosterone-induced (0.25 mg/rat) mitotic activity of the seminal ...
Changes in the number, proliferation rates, and bcl-2 protein immunoexpression of epithelial and periductal cells from rat epididymis during postnatal development
Basal cells cell proliferation
2009/2/18
To investigate 1) the correlation between the proliferative activity of epididymal epithelium plus myoid cells and the increase in the number of these cells and 2) the role of the basal epithelial c...
Pituitary control of proliferation and differentiation of Leydig cells and their putative precursors in immature hypophysectomized rat testis
Testis rat development Leydig cells steroidogenesis
2009/2/17
The objective of this study was to determine the effects of pituitary hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], growth hormone [GH], and prolactin [PRL]) on interstit...
Increased proliferation of Leydig cells induced by neonatal hypothyroidism in the rat
Propylthiouracil goitrogen cell kinetics ontogeny mitosis puberty
2009/2/16
Treatment of male rat pups with the reversible goitrogen 6-n-propyl-2-thiouracil (PTU), administered by adding 0.1% PTU to the mother's drinking water from birth through weaning, increases adult t...
Effect of TGF-beta 1, TGF-alpha, and EGF on cell proliferation and cell death in rat ventral prostatic epithelial cells in culture
Prostate epithelium TGF-91 TGF-a EGF apoptosis
2009/2/13
A tissue culture system for rat prostatic epithelial cells was developed, and the effect of epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and transforming growth facto...
Cell proliferation in the dorsal and lateral lobes of the rat prostate during postnatal development
Cell proliferation dorsal lateral lobes rat prostate postnatal development
2009/2/12
We have shown previously that cell proliferation occurs throughout the ducts of the rat ventral prostate during its postnatal development. Our objectives herein were to identify and quantify proli...
Effects of hypophysectomy and alterations in spermatogenic function on Leydig cell volume, number, and proliferation in adult rats
Pituitary spermatogenesis luteinizing hormone Leydig cell proliferation
2009/2/6
The two major objectives of this study were to determine (i) whether the pituitary is required to maintain Leydig cell number per testis, and (ii) whether alterations in spermatogenic function in ...
Rapid Proliferation of Prostatic Epithelial Cells in Spontaneously Hypertensive Rats: A Model of Spontaneous Hypertension and Prostate Hyperplasia
Bromodeoxyuridine cell culture Alamar Blue growth
2008/12/19
Spontaneously hypertensive rats (SHRs), a commonly used model of genetic hypertension, exhibit features of glandular hyperplasia of the ventral prostate, including the narrowing of acini with epitheli...
Balance of Apoptosis and Proliferation of Germ Cells Related to Spermatogenesis in Aged Men
Apoptosis proliferation Bcl-xl aging spermatogenesis
2008/12/19
To clarify whether germ cell apoptosis is related to a decrease of germ cells in the aged testis with impaired spermatogenesis, we investigated the apoptotic rate of each germ cell type. Testicular ...